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Regular follow-up every 412 weeks during initiation and dose titration, then every 36 months once stable, ensures appropriate safety surveillance for this inadequately studied combination

Appl Microbiol Biotechnol 106 , 19051917 (2022)

Kordzadeh-Kermani, V., Dartoomi, H., Azizi, M., Ashrafizadeh, S

Fumarate accumulation has been demonstrated in activated immune cells, and this event inhibits KDM5 histone demethylase activity, thus, promoting the transcription of promoters of TNF- and IL-6 cytokines (49)

Ribas V, et al