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Because the core mechanism papers were retracted, even the premise that Dihexa potently engages HGF/c-Met in a living human brain at community-reported doses is not established fact

it significantly slows gastric emptying and directly impacts the appetite-regulation centre in the hypothalamus

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The optimal approach requires individualised assessment considering disease activity, nutritional status, comorbidities, and patient preferences, delivered through multidisciplinary collaboration between gastroenterology, dietetics, and weight management services