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In a recent phase I study, retatrutide, a triple glucagon/GIP/GLP-1 receptor agonist, significantly reduced body weight and improved glycemic control, exhibiting a safety and tolerability profile similar to other incretin formulations in study participants, and body weight continued to decrease steadily after a single dose until the end of the study [105] (Figure 6)

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In the first nine months of 2023, 3.2% of Massachusetts commercial members were prescribed a GLP-1 drug, a seven-fold increase from 2018, when 0.5% of members were prescribed one of these medications