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The future lies in developing allosteric modulators or subunit-selective antagonists (particularly for GluN2B-containing receptors) that can precisely modulate pathological hyperactivity in the auditory pathway without disrupting essential NMDA receptor functions elsewhere in the brain, thereby offering a more effective and tolerable treatment strategy for tinnitus (Rafe et al., 2024

doi: 10.1097/HC9.0000000000000129 47

Transforming growth factor beta 1 (TGF1) plays a significant role in fibrosis associated with diabetic kidney disease

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But this is far from a fatal flaw

doi: 10.1016/j.cmet.2024.11.003 33 WeaverREDonnellyDWabitschMGrantPJBalmforthAJ