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However, because of their glucose-dependent mechanism of action, these agents tend to have a more significant effect on postprandial glucose than on fasting BG (40 mg/dL vs

Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats

Some subjects may require 25-50% dose reductions to maintain acceptable side effect profiles

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Extensions of indications were subject to the same timeframe as a de novo assessment