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The transmembrane protease-activated receptor 2 (PAR-2), which is expressed on keratinocytes and has an important role in the formation of melanocyte dendrites and the phagocytosis of melanosomes by keratinocytes [129, 130], could also be specifically blocked by compounds to decrease epidermal pigmentation [131]

Huang, X., Luan, B., Wu, J

Nature 611 , 358364 (2022)

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By converting to its active forms within the body, it supports methylation and the synthesis of nucleic acids and amino acids, which are vital for maintaining healthy nerve cells and forming red blood cells, thus correcting Vitamin B12 deficiency and associated symptoms

Synthesizing eight randomized controlled trials ( n = 2372), this study showed that weight regain after discontinuation is temporally predictable, proportional to initial weight loss, and differs between compounds