doi: 10.1016/j.clnu.2022.07.041
The USA is projected to record a 19.4% CAGR from 2026 to 2036 as coverage pathways and high treatment need create demand for coordinated support
Advances in histopathology and integrated microbiological and molecular diagnostics are improving recognition where clinical cues are muted or misleading, with growing emphasis on the continuum between colonisation, superficial infection, and early invasive disease in this population
In one trial of people with obesity and knee osteoarthritis, top-line results released in late 2025 showed that those receiving 12 mg weekly achieved 2226% average weight loss over 68 weeks , while the placebo group lost only around 2.5%
However, retatrutide remains unlicensed in the UK it has not received MHRA or EMA approval and no officially sanctioned prescribing schedule exists
CLINICAL TRIAL EVIDENCE FOR GLP-1 RAs IN MASH Table 2 provides a summary of phase 2 and phase 3 studies examining GLP-1 RAs and dual or triple agonists (aiming glucagon, GIP, and GLP-1 receptors) in individuals with MASLD/MASH, where hepatic biopsies were used to evaluate liver outcomes [3,5,10,11,15,22-25,44-52]