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In addition to these widely used AOMs, Exenatide, one of the earliest GLP-1 RAs approved by the FDA and EMA for T2DM management, is not indicated for weight management but remains clinically relevant, particularly in older adults with comorbid obesity and T2DM, given its long-term clinical experience and established tolerability profile [26,27,28]

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Reconstitution: The process of turning a lyophilized powder back into a liquid form for research

GLP-1 receptor agonists like semaglutide mimic the effects of GLP-1, a hormone that is released after meals to signal satiety and reduce food intake

[6] [4] Any changes in sweating patterns are more often driven by increases in physical activity, ambient temperature, dietary composition, and individual factors such as fitness level and acclimatisation rather than by the calorie deficit itself