how long has glp 1 been used A timeline of GLP- discovery and clinical development. Created in Mapping the effectiveness and risks

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The inward eutrophic remodelling involves reduction in the size of the lumen, media thickening, improved media to lumen ratio, and little alteration in the cross-sectional area of the media [76], while the hypertrophic remodelling involves an enhancement in the cross-sectional area of the vascular wall, size of the cell and accumulation of ECM proteins like collagen and fibronectin [77]

There is no definitive timeline for supplementation

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B.et al (2006)