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High levels may indicate a microbiome imbalance, gut inflammation, sluggish bile flow, liver inflammation, or cirrhosis of the liver

Fu and Kurzrock, 2010)

This indicates that a substantial part of the GSH pool is in an oxidized state in the gastrointestinal lumen, which is mainly related to the fact that intracellular levels of GSH and other components of the redox environment are more heavily regulated by the cell as compared to the redox environment of the extracellular space ( Dietary GSH did not change the GSH level in the mucosa, liver, and erythrocytes Previous research reported that piglets endure decreased GSH levels and redox imbalance following weaning (58)

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