(In full transparency, her team disclosed that Williamss husband, Alexis Ohanian, is a Ro investor and on the board.) Below, Williams talks to ELLE about why she decided to start using a GLP-1 and the diet-culture myths she hopes the drug will help dismantle
I understand that that exists with, you know SSRIs and things like that, but its even wilder to think that little voice that tells you this one time is not gonna hurt, that rationalization that you do to yourself, that feels like you, but in fact, it can be just a chemical reaction inside your brain
Tirzepatide SURMOUNT-1 (2022) and SURPASS-2 (2021) SURMOUNT-1 (Jastreboff et al., NEJM 2022): 2,539 non-diabetic adults with BMI 30, 72 weeks of tirzepatide 15 mg/week: Weight loss: 20.9% (vs 3.1% placebo) 91% of participants 5% loss, 56.7% 20% SURPASS-2 (Fras et al., NEJM 2021): 1,879 T2D patients head-to-head vs semaglutide 1 mg: HbA1c: 2.30% (tirzepatide 15 mg) vs 1.86% (semaglutide) Weight loss: 11.2 kg vs 5.7 kg Tirzepatide statistically outperforms semaglutide on both HbA1c and weight in a head-to-head trial a rare outcome in incretin pharmacology
[16] [17] Healthcare professionals should provide clear written and verbal instructions on site rotation during treatment initiation and reinforce these principles at follow-up appointments
The discovery and development of liraglutide and semaglutide
A lyophilised powder supplied in a sealed research vial for stability and laboratory handling
