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This is one of the most common combinations in clinical practice, given the high rates of depression and anxiety in patients with obesity

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doi: 10.1016/S0140-6736(08)61246-5 36 HernandezAFGreenJBJanmohamedSD'AgostinoRBGrangerCBJonesNPet al

The data showed significant improvement in -cell function and glycemic control, as assessed by fasting, postprandial, and overall (AUC 024h ) glucose and glucagon responses, as well as insulin secretion rate, among those with T2D who received semaglutide

29 Most notably, they found a rapid decrease in depressive symptoms with a mean decrease within 8 days of treatment