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ABCC1 expression depends on Nrf2 activation and translocation to the nucleus [33]

Furthermore, it was also responsible of in vitro endothelial cells conversion into a pro-inflammatory phenotype, characterized by increased expression of tissue factor, thrombin-activatable fibrinolysis inhibitor and plasminogen activator inhibitor [65]

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Importantly, observed sweet aversion diminished after reversal of the surgical procedure which was interpreted as an inducible change in taste perception

The results revealed that low serotonin levels weakened communication between the amygdala (which processes emotions like anger) and the prefrontal cortex (which regulates emotional responses), impairing the brains ability to control irritability and anger, leading to heightened emotional reactions

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