As summarized by Stier, Vos, and Kenley in 2013, the pre-specified primary endpoint for statistically significant weight change across the dose range and study duration was not met, while the compound's tolerability profile remained comparable to placebo
Mice were sacrificed when their total tumor volume reached 2000 mm 3 according to the approved animal protocol (in 3 weeks), so the total experimental timeframe was around 5 weeks
The skin changes typically show up after several sessions, and they're gradual
Tan, S., Khumalo, N
88: 142-149 (2025) Ostergaard S, Olsson L, Nielsen J
Unique, common, and interacting cortical correlates of thirst and pain