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Support for this notion comes from instructive pathological feature found at the other end of the temporal spectrum, the so-called pre-active lesion, consisting of small clusters of activated microglia seen throughout the MS NAWM, accompanied by axonal and oligodendroglial injury (van Noort et al., 2011

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Therefore, in future studies it will be exciting to identify more complex substrates of Mia40 that might interact with the reduced oxidoreductase in one of the above described processes so as to clarify the role of reduced Mia40 in the IMS

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The stomach would digest the peptides before they reached the blood