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In contrast, serine phosphorylation of IRS proteins inhibits this signaling cascade ( The ratio of serine-phosphorylated IRS to total IRS is widely used as a biomarker of insulin resistance in both brain and peripheral tissues

Further mechanistic studies have found that treatment with TMZ promoted cardiac Nrf2 expression, indicating that TMZ enhanced the clearance of oxidative stress by activating the GSH system through the Nrf2 signaling pathway [210]

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Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence