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Importantly, metformin treatment in vivo in 3Tg-AD mice corrects the impaired aPKC-CBP pathway to repress Mgll expression, significantly rescuing impaired adult neurogenesis, preventing spatial memory decline, and reducing A accumulation

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10.3389/fendo.2024.1366940 Front Endocrinol

Bacterial culture supernatant (CS) preparation Exponentially growing cultures of lactobacilli in MRS broth, were washed thrice with PBS and resuspended in cell maintenance MEM without antibiotics

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Doxorubicin was selected as a training compound for three reasons: i) the quinone moiety, present in doxorubicin, is acknowledged as a notorious redox cycler