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A solution to induce an acute hepatic toxicity and a rapidly progressing encephalopathy with severe seizures in rats may be a single paracetamol overdose (5 g/kg intraperitoneally) that excided the regimens previously used (1, 2, 6, 11)

Ibez-Fors, V., Bovea, M

B12 is a water-soluble vitamin

Adverse event monitoring Document each adverse event the patient reports together with your clinical response and any FDA MedWatch reporting (voluntary for physicians, required for manufacturers)

Use Bacteriostatic Water for research requiring multi-dose stability