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High Oxygen Consumption: The brain consumes about 20% of the body's oxygen despite comprising only 2% of body weight, leading to a higher rate of ROS production in neurons

To protect themselves from irreversible damage and prevent the cell from undergoing apoptosis (programmed cell death), the mitochondria initiate a defensive mechanism known as the Cell Danger Response (CDR)

Nonalcoholic fatty liver disease: A challenge from mechanisms to therapy