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[1] [5] Other Notable Side Effects include: Injection site reactions erythema, pruritus, or discomfort at the injection site Fatigue (3-7% of patients) Hypoglycemia risk increases when combined with insulin or sulfonylureas [1] [3] Increased heart rate modest elevation (2-4 beats per minute on average) Oral contraceptive interaction tirzepatide may reduce the absorption of oral contraceptives during initiation and dose escalation

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This allows the same vial to be used multiple times while maintaining a sterile environment when proper laboratory handling procedures are followed