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The jump from 1mg to 4mg produced nearly double the weight loss, from 8.7% to 17.1%, suggesting that the glucagon component only becomes meaningfully active somewhere in that dose range

That conclusion turned out to be incomplete

By week 12, clinical trial participants achieved an average of 8.7% body weight reduction across all dose groups

Recent findings show that participants on the highest dose of retatrutide lost an average of 28.7% of their body weight over 68 weeks

This article outlines dosing timing, safe administration, side effects, and current UK availability