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After activation of the TGF pathway in PSCs cultured in low glucose, the expression levels of -SMA and collagen I were significantly upregulated

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Additional functional studies and more clinical investigations are needed with larger sample size and improved study design to verify PLC association with cancer risk

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The studies also had some shortcomings, as some only administered fluoxetine at the end of pregnancy and could not assess the effects of the drug throughout the entire pregnancy period, some did not explore the specific mechanisms of fluoxetine-induced fetal acidosis, hypocalcemia, and altered maternal estradiol metabolism, and some failed to assess the maternal and fetal health status over a long-term follow-up period