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Ann Thorac Surg 103(6):1710-1714, 2017

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These formulation exhibits a encapsulation efficiency ranging from 79.65 3.84%,These complexes had a size between 300 and 500 nm, particle size of 18.74 9.748 nm, a polydispersity index (PDI) of 0.198 0.01, Permeation data indicate that after 24 h, methotrexate was released from the nano-emulsion at 76.83 4.98 g/cm 2 with a flux rate of 2.385 0.61 g/cm 2 /h [160]