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The available evidence suggests that older adults derive similar clinical benefits as younger adults with comparable weight loss and an equivalent associated impact on obesity-related complications, with likely improved adherence to treatment regimes

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Canadian Family Physician, 68 (11), 796

Physiological oral mucosal melanin hyperpigmentation Physiological oral mucosal melanin hyperpigmentation manifests clinically as asymptomatic, single or multiple, well-demarcated or ill-defined patchy or uniform macules which range in colour from light to dark brown or black, and are of variable size and configuration

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GSH accumulation within TLS was also confirmed by desorption electrospray ionizationmass spectrometry imaging (Supplemental Figure 2)