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For fitness instructors, health coaches, medispa professionals, and individuals interested in cutting-edge metabolic interventions, several key principles should guide decision-making: Core Principles: Evidence matters Monotherapy data for both compounds is strong

Gastrointestinal side effects may overlap (nausea from semaglutide, diarrhea from metformin), so starting both at low doses and titrating gradually minimizes discomfort

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Because they felt fine