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Complementarily, IGF-1R preferentially activates IRS-2 [120] as it was found that IRS-2 contains a KLRB domain that functions to block the tyrosine kinase domain in the cytoplasmic region of the IR, and that such does not happen in the IGF-1R

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Proc Natl Acad Sci U S A (2006) 103(20):763742.10.1073/pnas.0601638103 132 SasakiAYasukawaHSuzukiAKamizonoSSyodaTKinjyoIet alCytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain