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Research has found that TAM-derived TGF-1 regulates the expression of hepatic leukemia factor (HLF) by modulating SMAD3, resulting in transactivation of gamma-glutamyltransferase 1 (GGT1)
(2011) recently confirmed this in mouse locus coeruleus and further established that the impairment is arrestin-dependent because recovery from desensitization was normal in - arrestin2 knockout mice
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It is produced by the body, recycled continuously and is found in fairly high concentrations in most human cells
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