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The SUSTAIN and STEP trial data consistently showed cardiometabolic improvements in lipid profiles alongside weight loss, which is part of why semaglutide received approval for cardiovascular risk reduction in certain populations

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Elieh-Ali-Komi D, Cao Y (2017) Role of mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

Upregulated expression of Tumor necrosis factor alpha (TNF-) promotes the transcription, that is the formation of mRNA transcripts, of Nuclear factor kappa B (NF-B)