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[10] [11] It's important to understand that GLP-1 medications are initiated at a low dose and gradually increased over several weeks to minimise gastrointestinal side effects such as nausea and vomiting

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J Clin Epidemiol 159:7984

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The discontinuation rates due to adverse events, which were comparable to placebo, suggest that the transition to oral orforglipron is generally well-tolerated by patients already acclimated to incretin therapy