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The same results were obtained when PV1-BSOr (VP3, Q178L) was used instead of the wt virus (Figure 8B)

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These data are consistent with one of two scenarios, either (1) direct peptide-stimulated inhibition of GLP-1R and Y1-R on -cells, or (2) indirect peptide-mediated insulin release leading to inhibition of glucagon release, as observed in previous studies 50,51

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