This finding does not establish causality, but it is consistent with a model in which robust mitochondrial peptide signaling is a feature of successful aging rather than a peripheral correlate
Succimer chelation improves learning, attention, and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure
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Furthermore, addition of IGF binding protein-3 (IGFBP-3) antagonized the anti-apoptotic effects of GH, which suggested that exogenous GH promoted local IGF-1 production that prolonged follicular survival (51)
[DOI] [PubMed] [Google Scholar] 229.Martell A.E., Smith R.M