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According to research principles: Clinical trial results represent average outcomes under ideal conditions with: Highly selected participants (extensive exclusion criteria) Monthly professional monitoring and support Free medication (eliminates cost barriers) Structured lifestyle interventions High adherence rates Real-world results may differ due to: Variable medication adherence Different lifestyle modification levels Varying dose levels reached Cost/access barriers affecting consistency Less frequent monitoring Individual metabolic differences Some individuals exceed clinical trial results

European Medicines Agency (2024) Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC) 8-11 April 2024