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The resulting diminishment of Hes1 expression and other Notch effectors compromises the sphere-forming ability of CSCs and their capacity to maintain the undifferentiated state (72, 73)

Cysteine-rich protein 61 (CCN1) domain-specific stimulation of matrix metalloproteinase-1 expression through V3 integrin in human skin fibroblasts

Others benefit from switching to a lower-dose tirzepatide protocol or to compounded semaglutide alone, which may produce less pronounced gastric slowing in certain genetic profiles

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