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Studies that describe alterations in the functional connectivity of the cerebral networks, particularly within the networks that involve the amygdala and insular cortex, can better explain the role of brain anomalies in CVS.41 In a case-control study, patients with CVS showed increased functional integrity of salience intrinsic connectivity to the middle/posterior insula, a key region of the brain for nausea and viscerosensory processing.41 It is possible that this neuronal hyperexcitability and a lower threshold for triggering specific patterns within the CNS predispose to the triggering of stereotypic vomiting episodes in CVS

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The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials