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In contrast, mitochondrial PRDX3 undergoes hyperoxidation during lipid peroxidation stress and translocates to the plasma membrane, where it suppresses cystine uptake, depletes intracellular GSH, and amplifies ferroptotic execution 114

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Martinez-Zamudio R, Ha HC

Glucagon like peptide-1 (736) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus

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DTR-QoL scores and estimated treatment differences between orally administered semaglutide and dulaglutide for the individual domains and the overall score were generally similar to those reported above for the treatment policy estimand when assessed using the trial product estimand (Fig