Always administer under professional guidance to minimize any risks
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Recommending safe alternatives or adjustments to the treatment plan
Metformin is often considered for women with PCOS who have metabolic features or impaired glucose regulation, particularly as it has a well-established safety profile, oral administration, and cost-effectiveness
Moreover, existing data indicate that single-target GLP-1RAs such as SEMA and liraglutide show promising capabilities for fibrosis improvement, and the initial success of the dual agonist tirzepatide suggests potential benefits of dose titration therapy in the monotherapy management of MASLD