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Liposomal technology protects it through digestion for higher absorption
Pre-clinical data in multiple cancer cell lines (including breast, ovarian, pancreatic, colon, non-small cell lung, prostate, thyroid, hepatocellular and oral squamous cell carcinomas and melanoma) have shown the potentiation by HDIs of the effects of topoisomerase I inhibitors (camptothecin, irinotecan, topotecan) topoisomerase II inhibitors (epirubicin, doxorubicin, etoposide, mitoxantrone) and other DNA-damaging agents (cisplatin, oxaliplatin, bleomycin)
5a, GSTP-silencing facilitated the depolarization of the mitochondria membrane
Hlavica P, Lewis DFV: Allosteric phenomena in cytochrome P450-catlyzed monooxygenation
Schidt et al