However, the Wegovy pill may not be suitable for everyone
Thirdly, GLP-1 agonists slow gastric emptying, leading to a delayed absorption of nutrients and a prolonged feeling of fullness, which can contribute to reduced food intake and weight loss
The amount of oral intake needed to achieve gastric and intestinal fullness and signal satiety to the brain through the gut-brain axis can overwhelm the evolutionarily determined metabolic capacity of peripheral organs such as liver, pancreas, fat tissue, and muscles
She later switched to Wegovy
On tolerability, retatrutide's GI adverse event rate is higher than tirzepatide's at matched mechanistic dose, which is the tradeoff for the additional mechanism
That helps to slow down digestion