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Synthesis of Amodiaquine Quinoneimine (AQ-QI) and Desethylamodiaquine Quinoneimine (DEAQ-QI) Synthesis of AQ-QI and DEAQ-QI was adapted from a method published previously, with a few modifications ( in vacuo and then applied to a silica-60 column to remove the tracing AQ or DEAQ

Alpha and beta hydroxy acids Exfoliating acids like glycolic acid, salicylic acid, and lactic acid can interfere with copper peptide efficacy

Molecular Weight: ~1,024.2 g/mol

Different extractions might contain different amounts of the active component

Furthermore, the effects of an IV drip are temporary

FIGURE 6 Next, we performed debiased sparse partial correlation (DSPC) networking modeling and metabolite ontology analysis to evaluate pathway-informed correlations and metabolite localization, respectively