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Based on the damage to thyroid cells caused by low Se level, researchers have raised the possibility that Se supplementation may be beneficial in GD and have conducted a series of clinical studies (1618, 20, 2830)

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Slower dose titration or temporary dose reduction may be appropriate if symptoms are severe

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Additionally, cells expressing both receptors show a 65% attenuation of Ca 2+ accumulation in response to ghrelin or the ghrelin agonist MK-0677, with this attenuation being mostly restored by the 5-HT 2C specific antagonist RS102221