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Semaglutide may influence factors related to stone formation, such as urinary composition and weight management, but its direct impact on kidney stones is not yet clearly established

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Understanding the variables helps set expectations and identify where adjustments might be needed

There is considerable debate within the industry, particularly on whether to develop agonist or antagonist drugs targeting GIPR

People also use them off-label to help with weight loss, as they curb hunger signals

Compliance with Ethics Guidelines As this was a non-interventional, retrospective analysis of claims data from de-identified patients, institutional review board approval was not required