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Despite its high programmability, the platforms therapeutic utility was initially limited by modest in vivo performance

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Previously, it was shown by experiments with purified proteins that proteins like hemoglobin (Grune et al, 2003), calmodulin (Ferrington et al, 2001) and ferritin (Shringarpure et al, 2003) that are not susceptible to degradation by the 20S proteasome under basal conditions, become 20S substrates following oxidative stress

Stem Cells 39 (4), 458466

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