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It is explicit that they do not suppress appetite or directly regulate blood glucose, which is what separates them from semaglutide's action at GLP-1 receptors

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By binding with IGF-1, IGF-2, and insulin, IGF-1R activates downstream pathways including phosphoinositide 3 kinase (PI3K)/AKT and Ras/extracellular signal-regulated protein kinase (ERK) pathways, 1 two frequently activated pathways in colorectal cancer

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