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Any of those can point to a bleeding or vascular issue that deserves evaluation before continuing therapy

If you've missed a dose, don't skip the next scheduled dose or increase it to compensate

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Additionally, you can request a referral from your primary care provider

Correspondence Address : Devinder M Thappa Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry - 605 006 India Introduction The human skin color is one of the most perceptible phenotypic variations among humans and is determined primarily by the type and amount of melanin synthesized within melanosomes and the pattern of melanosome distribution within the melanocytes