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Sites of protease/peptidase vulnerabilities in GLP-1 were removed by amino acid substitution and the peptide backbone was bis-lipidated to promote MEDI7219 reversible plasma protein binding without affecting potency

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In some patients, both approaches are useful during the same operation

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Bauer A.Z., Swan S.H., Kriebel D., Liew Z., Taylor H.S., Bornehag C., Andrade A.M., Olsen J., Jensen R.H., Mitchell R.T., et al

In addition to regulating fat metabolism, Liu et al