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Kraguljac NV, Reid M, White D, Jones R, den Hollander J, Lowman D, et al

Because it is used up quickly during times of stress, illness, or toxin exposure, many people find that their natural production cannot keep up with the body's demands

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Bayesian updating can then incorporate emerging RCT and cohort evidence, revising effect estimates and widening or narrowing credible intervals as the evidence base evolves