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Robeldo et al

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) improves mood in healthy adults over 4 weeks in a double-blind, parallel, randomized, placebo-controlled clinical trial

Experts caution that the evidence is mainly anecdotal, and there are potential risks such as liver or kidney issues and allergic reactions

Some affected individuals have a less severe form of the condition and do not develop signs and symptoms until early childhood

Comparative evaluation of quetiapine plus lamotrigine combination versus quetiapine monotherapy (and folic acid versus placebo) in bipolar depression (CEQUEL): a 2 2 factorial randomised trial