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Moreover, the available clinical data reveal that these peptides have great safety profiles and are well-tolerated even in long-term studies

Defecation disorders, including dyssynergia (the puborectalis is spastic) and anismus (the anal sphincter does not relax), could reduce emptying of the left colon which leads to abdominal pain or distension [22]

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A 1992 study by Hartman et al

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Interfering with that process can compromise the result