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Although glucose uptake remains intact, downstream utilization of both glucose and fatty acids is markedly impaired, coinciding with reduced mitochondrial membrane potential, diminished respiratory capacity, and blunted glycolytic flux

Levy D, Ronemus M, Yamrom B, Lee YH, Leotta A, Kendall J, et al

HCV infection can induce ROS-mediated oxidative stress, leading to the formation of 8-hydroxydeoxyguanosine (8-OHdG), which is an indicator of oxidative DNA damage 83

Along the same line, accumulating evidence is drastically scaling back the supposed role of ACE2 upregulation by renin-angiotensin inhibitors in COVID-19 severity (Verdecchia et al., 2020)

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