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discovered that restricting the intake of specific amino acids (particularly methionine, Met) could significantly inhibit tumor growth in rats ( Studies in 1976 further demonstrated that although intracellular Met levels in cancer cells are normal or even elevated, their proliferation remains absolutely dependent on exogenous Met, a contradictory occurrence known as the Hoffman effect ( in vivo ( Intervention strategies targeting tumor metabolism can be traced back to Otto Warburgs theory of aerobic glycolysis in cancer (the Warburg effect) proposed in the 1920s ( 2 Methionine metabolism In mammals, methionine is a crucial amino acid
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